News

2018/01/05
LLTech at Photonics West 2018 – 27 January – 1 February 2018
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2017/03/02
New publication on quality control and primo-diagnosis of transurethral bladder resections with full-field OCT
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2017/02/01
Meet LLTech at Agora Biotech investment event – February 22nd
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2017/01/28
LLTech at Photonics West 2017 – San Francisco 28 January – 2 February 2017
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2016/11/18
Real-time analysis of colorectal polyps during coloscopy
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The Light-CT Scanner is a high-resolution imaging device for subcellular-level biological tissue imaging. It performs non-invasive and non-destructive real-time optical biopsy.

In depth microscopic tissue visualization in a fast, non-destructive manner without the use of contrast agents could improve the clinical diagnostic process.

LLTech’s optical technology is based on Full Field Optical Coherence Tomography (FFOCT), a technique that enables volumetric image capture on tissue samples at micron resolution in 3D. The technology intends to assist diagnosis, particularly of cancer, in skin, breast, prostate, brain etc, as well as quality control of biopsies.

The Light-CT system is a high-resolution (1µm 3D) pathology scanner that performs optical slicing beneath the tissue surface at selected depths. Using two different acquisition methods, called Full-Field Optical Coherence Tomography (FFOCT) and Dynamic Cell Imaging (DCI), Light-CT produces images showing both the tissue architecture and the intracellular metabolic activity without sample processing or staining. This multi-modal information comes from the system abilities to detect variations of light retro-diffusion and to record metabolism-induced residual intracellular movements of freshly excised tissue.

FFOCT (left) and DCI (right) images of the same breast tumor sample. Bright collagen fibers indicating stromal reaction are visible on the FFOCT image. The DCI image reveals individual cancer cells and highlight the invasion of these cells into the collagen.

In the context of tissue imaging for cancer diagnosis, LLTech anticipates the following benefits:

  • Better image quality: the full-field OCT technology employed by the Light-CT Scanner is the sole technique to offer axial resolution (i.e. in the vertical, z-axis) of 1 µm, which gives the best image clarity and precision.
  • Speed (rapidity of diagnosis): the technology currently enables image capture on a 1 cm² region of tissue in 4 to 5 minutes, thereby enabling immediate quality control of biopsies.
  • Avoiding patient recall in the event of complex biopsies that require hospitalization and/or anesthesia.
  • Non-destructive technology that allows reuse of the biopsy: no need for dyes, contrast agents or tissue freezing
  • Analysis can be carried out remotely
  • Ease of use: LLTech products can be employed directly. No calibration or complex set-up procedure is necessary. User training is completed in under half a day.

The following video demonstrates the use of the Light-CT scanner.

 

Intended Use Statement: The Light-CT Scanner is intended to acquire, store, retrieve, display, and transfer optical coherence tomography images of unsectioned excised surgical tissue for review by physicians to assist in forming a clinical judgment. The Light-CT Scanner is not intended as a primary means of diagnosis. The Light-CT Scanner is certified for research use only.