News

2017/02/01
Meet LLTech at Agora Biotech investment event – February 22nd
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2017/01/28
LLTech at Photonics West 2017 – San Francisco 28 January – 2 February 2017
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2016/11/18
Real-time analysis of colorectal polyps during coloscopy
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2016/10/14
New publication on FFOCT imaging of humanized orthotopic model of hepatocellular carcinoma in immunodeficient mice
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2016/10/13
Meet LLTech at JFR 2016 – Paris 14-17 October 2016
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2017/02/01
Meet LLTech at Agora Biotech investment event – February 22nd

The LLTech team and advisors will be present on February 22nd for the Agora Biotech Funding event.

The team will showcase the product, present the company and the investment opportunity.

For further information and request an invitation please register at www.biotech-agora.com

logo-biotech-agora-simple

Biotech Agora a pour vocation de faire découvrir aux investisseurs des sociétés dans le domaine des Biotechs et des Sciences de la Vie qui offrent des innovations de rupture. 

Biotech Agora met en lumière des sociétés de pointe, cotées et non cotées, et contribue au financement de l’innovation en favorisant les rencontres entre dirigeants et investisseurs.

2017/01/28
LLTech at Photonics West 2017 – San Francisco 28 January – 2 February 2017

In BiOS, LLTech will present the latest clinical results and developments of the Light-CT Scanner. More details will be given during the following talks:

Quality control and primo-diagnosis of transurethral bladder resections with full-field OCT, 28 January, 10:40 – 11:00 AM
Skin cancer margin analysis within minutes with FFOCT, 28 January, 11:10 – 11:30 AM
Non-contact full-field optical coherence tomography: a novel tool for in vivo imaging of the human cornea, 29 January, 1:45 – 2:00 PM
Pancreatic cancer diagnosis based on full field OCT and dynamic full field OCT, 30 January,  10:40 – 11:00 AM
Extracting relevant information for cancer diagnosis from dynamic full field OCT through image processing and learning, 31 January, 4:45 – 5:00 PM

2016/11/18
Real-time analysis of colorectal polyps during coloscopy

The LLTech device was used this week under real coloscopy conditions at Cochin Hospital, Paris. Excised polyps were imaged within minutes by FFOCT in the coloscopy room, and the images transmitted to the pathologist office through the hospital network. The pathologist could thus give a feedback to the endoscopist during the coloscopy on the malignancy of the polyp.

Note: this experiment was conducted under a research study, which did not alter the patient management. 

 

2016/10/14
New publication on FFOCT imaging of humanized orthotopic model of hepatocellular carcinoma in immunodeficient mice

Multimodal imaging of a humanized orthotopic model of hepatocellular carcinoma in immunodeficient mice

Wu T, Heuillard E, Lindner V, et al. Multimodal imaging of a humanized orthotopic model of hepatocellular carcinoma in immunodeficient mice. Scientific Reports. 2016;6:35230. doi:10.1038/srep35230.

Abstract

The development of multimodal strategies for the treatment of hepatocellular carcinoma requires tractable animal models allowing for advanced in vivo imaging. Here, we characterize an orthotopic hepatocellular carcinoma model based on the injection of luciferase-expressing human hepatoma Huh-7 (Huh-7-Luc) cells in immunodeficient mice. Luciferase allows for an easy repeated monitoring of tumor growth by in vivo bioluminescence. The intrahepatic injection was more efficient than intrasplenic or intraportal injection in terms of survival, rate of orthotopic engraftment, and easiness. A positive correlation between luciferase activity and tumor size, evaluated by Magnetic Resonance Imaging, allowed to define the endpoint value for animal experimentation with this model. Response to standard of care, sorafenib or doxorubicin, were similar to those previously reported in the literature, with however a strong toxicity of doxorubicin. Tumor vascularization was visible by histology seven days after Huh-7-Luc transplantation and robustly developed at day 14 and day 21. The model was used to explore different imaging modalities, including microtomography, probe-based confocal laser endomicroscopy, full-field optical coherence tomography, and ultrasound imaging. Tumor engraftment was similar after echo-guided intrahepatic injection as after laparotomy. Collectively, this orthotopic hepatocellular carcinoma model enables the in vivo evaluation of chemotherapeutic and surgical approaches using multimodal imaging.

2016/10/13
Meet LLTech at JFR 2016 – Paris 14-17 October 2016

LLtech will showcase the 7 times faster version of the Light-CT Scanner, integrating the latest camera technology and a new GPU-based stitching algorithm developed by LLTech and INRIA (FR). This new product allows the 3D microscopic exploration of a 1-cm² ex vivo biopsy at cellular resolution in 1 minute.

Meet us on booth 114C, and listen to our latest results on prostate biopsies:
Lauréat du Prix SFR-Medicen : LLTech développe la radiologie à l’échelle cellulaire pour le diagnostic des biopsies en temps-réel, in session « Avancées en imagerie uro-gétinale masculine »,  Saturday January 15, 15:23.

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